JOSHUA MAYER | PHOTO

JOSHUA MAYER | PHOTO

Landscape Feature Effects on the Invasibility of Chicago Region Restored Prairies

By Robert Sherman   |   Environmental Science, Plant Biology & Conservation   |   NURJ Online 2015-16   |
May 1, 2016

Tallgrass prairie is one of the most endangered ecosystems in North America, with its current extent at less than one percent of its historical range. For this reason, there has been a large push within the field of restoration ecology to better understand restored prairies. One of the biggest threats that faces the prairie ecosystem is the invasion of non-native species, which can negatively affect the ecosystem...

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ENZYMLOGIC | PHOTO

ENZYMLOGIC | PHOTO

Structure-Function Analysis of Sds3, suppressor of defective silencing 3, a Key Component of the Histone Deacetylase-Containing Mammalian Sin3L/Rpd3L Corepressor Complex

By Yujia Ding   |   Department of Biological Sciences   |   Honors Thesis   |   NURJ 2014-15

At the most fundamental level, organisms must have a method to translate information stored in the genetic code into proteins that keep organisms alive. Gene transcription thus plays an important role in the survival of an organism and is predictably tightly regulated. Regulatory machinery exists at the molecular level and is of particular interest to researchers as there is a lack of understanding in how the structure of these complexes contributes to their function.

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ALLAN AJIFO | PHOTO

ALLAN AJIFO | PHOTO

Characterizing the Hippocampal Dentate Gyrus during Recent and Remote Trace Eyeblink Conditioning

By Lillian Chen   |   Department of Biological Sciences   |   Honors Thesis   |   NURJ 2014-15

In order to develop effective treatments for amnesia associated with dementia and Alzheimer's disease, the neural mechanisms underlying long term memory storage need to be better understood. The hippocampus is a brain region that has been widely studied for its role in memory processes given that it is often the area of the brain that is damaged in the amnesic condition. Currently, the role of the hippocampus during the consolidation of declarative memories is highly contested.

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A Petrologic Model for Hydrothermal Metamorphism in the Portage Lake Volcanic Series, Northern Michigan

By Ari Melinger-Cohen   |   Earth and Planetary Sciences   |   NURJ Online 2014-15

We developed a petrologic model to assess the timeline of hydrothermal metamorphism of the Portage Lake Volcanics series during the Proterozoic Eon. Altered basalts and conglomerates include a variety of mineral deposits that record the pressure, temperature, and compositional history of this hydrothermal fluid over one billion years ago. Mineralogical optical properties and microtextures are examined using petrographic microscopy in six samples from the Calumet and Hecla mines in Michigan, as well as...

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A Library of Cobalt (III) Schiff Base Complexes for pH-Triggered Protein Inhibition

By Viktorie Reichova   |   Department of Chemistry   |   NURJ Online 2014-15

Cobalt(III) Schiff base (Co(III)-sb) complexes inhibit histidine-containing proteins by interfering with structural or active sites. Through inhibition of proteins relevant to diseases processes such as cancer metastasis, Co(III)-sb complexes can be developed for therapeutic approaches. The Meade lab is developing pH-responsive, self-reporting Co(III)-sb complexes. Here, a library of Co(III)-sb complexes with modifications to the equatorial ligand was developed in an effort to enhance stability while retaining pH lability. Electron-withdrawing (chloride and phenyl) substituents were added to...

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Trinuclear Ruthenium Clusters for Electrochemical
Biosensor Development

By Hsiao-Tieh Hsu   |   Department of Chemistry   |   NURJ 2013-14

A biosensor is a non-invasive device that can detect biomolecular analytes associated with diseases. Electrochemical biosensors are useful due to their low cost, ease of use, and remarkable reproducibility. Previous studies show that electron transfer between...

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Phylogeny and Biogeography of Maclura

By Paya Sarraf   |   Department of Biological Sciences   |   NURJ Online 2014-15

Maclura, a genus of plants in the mulberry family (Moraceae), is comprised of twelve species that inhabit every continent except for Antarctica. The widespread distribution of Maclura, despite its limited number of species, brings up inquiries about its origination, dissemination and evolution.  The phylogeny of Maclura and its biogeography was examined through the use of molecular sequence data, fossil calibrations, and independent geological data. 

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Targeting MicroRNA-21 for Therapy Against Prostate Cancer Progression and Metastasis

By James Lee   |   Molecular Pharmacology and Biological Chemistry   |   NURJ 2011-12

With its ability to affect every organ and tissue through various mechanisms, cancer is one of the most complex diseases that we face. Prostate cancer is the most prevalent cancer in men; one in six men will be diagnosed with prostate cancer during his lifetime, and one in thirty-six men will die of the disease.1,2 The role of microRNA-21 (mir-21) in prostate cancer has not been clearly defined yet, and the goal of this experiment is to investigate how mir-21 affects prostate cancer progression and metastasis (invasion of other organs). Understanding its role might be a key in designing a new therapeutic approach to prostate cancer.

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